Time：4:00-5:30 PM, Monday, August 21, 2023

Venue: E10-222, Yungu Campus

Host: Li Deng, XU Yiming Endowed Chair Professor, School of Science

Speaker：  

Bing Xu

Professor of Chemistry, Brandeis University

Bing Xu, after receiving his BS and MS degrees from Nanjing University in 1987 and 1990, respectively, obtained his PhD in 1996 from the University of Pennsylvania. Before starting his independent research at the Hong Kong University of Science and Technology (HKUST) in Aug. 2000, he was an NIH postdoctoral fellow at Harvard University. Dr. Xu was a tenured professor at HKUST until Jul. 2008 before he returned to Boston. He currently is a professor in the Department of Chemistry, Brandeis University. He has made pioneering contributions to metallogels, multifunctional magnetic nanoparticles, self-delivery drugs, supramolecular hydrogels, and enzyme-instructed self-assembly for in-situ anticancer nanomedicine. His current research focuses on the applications of enzymatic noncovalent synthesis in materials, biology, and medicine.

Title:

Intracellular Peptide Assemblies for Cancer Therapy

Abstract:

Subcellular compartmentalization is a key feature of eukaryotic cells. Selectively targeting subcellular organelles, though holding many exciting opportunities for biomedicine, remains underdeveloped. Enzyme-instructed self-assembly (EISA), an approach that integrates enzymatic reactions and self-assembly, allows dynamic conversions from single molecules into larger supramolecular nanostructures for targeting subcellular organelles. In this talk, we discuss the use of EISA to generate intracellular peptide assemblies for targeting mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and nucleus. Particularly, we will show the use of EISA to generate peptide assemblies, as in-situ nanomedicine, for developing therapeutics to counter drug resistance and immunosuppression in cancer therapy.

Contact:

Sci-tech02@westlake.edu.cn