Time：1:15 - 2:30 pm, Thursday, April 20, 2023

Venue：E10-201, Yungu Campus     

Host: XU Yiming Endowed Chair Professor Li Deng, School of Sciences

Speaker: Xiaoming FENG, Professor, Sichuan University; Academician, the Chinese Academy of Sciences; Fellow, the Royal Society of Chemistry; Founder member, Chinese Chemical Society

Xiaoming FENG

Professor, Sichuan University

Academician, the Chinese Academy of Sciences

Fellow, the Royal Society of Chemistry

Founder member, Chinese Chemical Society

Title:

The Development of Privileged Chiral N, N'-Dioxide Ligands and their Utility in Asymmetric Catalysis

Abstract:

Asymmetric catalysis represents one of the most efficient and straightforward strategies to access chiral substances. It provides enantioenriched compounds and key technologies for the green and sustainable development in fields of pharmaceutical science, agricultural chemicals, and material science. Chiral ligands and catalysts play a central role in asymmetric catalysis. Over the past twenty years, Prof. Feng and coworkers have developed a new class of privileged chiral ligands and catalysts, namely, chiral N,N'-dioxide amides. Chiral N,N'-dioxide amides are not only used as organocatalysts but also employed as tetradentate oxygen-ligands to coordinate with main group metals, transition metals or rare-earth metals to form well-defined metal complexes (also known as Feng catalyst). Chiral N,N'-dioxide–metal complexes with unique electronic and steric features have been identified to competent catalysts in more than 70 types of enantioselective transformations. One of them, Roskamp-Feng reaction, was collected in the 3rd edition of Organic Syntheses Based on Name Reactions published by Elsevier. These new methods and strategies developed by Feng and coworkers provided facile and efficient accesses to bioactive molecules including drugs and drug candidates.

Contact: sci-tech02@westlake.edu.cn